Like everyone else, I was surprised to read the news this morning that Jeffrey Kindler, the change-minded CEO of Pfizer, Inc. was retiring after less than five years on the job. Who knows all of the factors that contributed to the decision. But what was so striking about the “official story” is that Kindler was so open about the fact that he was so damn tired.

Indeed, reading his quotes, you could feel the fatigue rolling off the page—fatigue that’s got to be familiar to lots of CEOs running companies in lots of different industries.

Here’s my take, for BNET, on the lonely life of the CEO—and how to get killer results without killing yourself in the process. You can find the article here.